Purpose: The objective of this research was to find out the impact of statin use and causing dry eyes and MGD associated with dyslipidemia.

Methodology: Quasi-Experimental study was conducted at Al-Nafees Hospital, Islamabad with a non-purposive sampling technique. The study comprised 100 participants who met the specified inclusion criteria. Group I included 50 patients who were advised to take statin along with eye lubricant thrice a day for a time period of 90 days. Group II consisted of 50 patients who took only statin for treatment of dyslipidemia.  All the participants were diagnosed case of dyslipidemia. Dry eyes assessment was performed by using Schirmer test and Tear Break up Time, and MGD was assessed using meiboscores. All assessments were carried out at the three follow-ups. First at the baseline at second follow-up (after one month of treatment) and third follow-up (after three months when treatment was completed).

Results: 83% of subject belongs to age group 41-45 and17% in age group36-40. Gender wise 53% male and 47% females. The mean scores of TBUT test were statistically significant within the groups (P-Value=0.00). Results of Schirmer Test at the baseline, first and second follow up. Significant differences were found at the baseline (P-Value= 0.008). MGF were statistically significant within the groups (P-Value=0.00). No significant association was found among cholesterol level and Schirmer test as (P-Value=0.096). For TBUT no significant differences were found at the baseline (P-Value= 0.324) and first follow up (P-Value=0.286) significant differences were present among the study groups at the second follow up (P-Value: 0.00).

Conclusion: The study has concluded with a finding that significantly improved results were observed in terms of OSDI score and tear-break-up time in the patients who had used lubrication for dry eyes with statins for dyslipidemia.

Keywords: Dry eyes, Dyslipidemia, lubricants, statin, Cholesterol