Resistance to antibiotics is one of the prime problems dealing with international health today, as well as significant reason of death over the globe. the aim of the study is to determine antibacterial effects of  fresh Neem (Azadirachta indica) leaves  and Methi (Trigonella foenum-graecum)  extracts against common resistant pathogens of Methicillin resistant staphylococcus aureus, , ESBL producing bacteria Escherichia coli,Klebsiella pneumonaie and Pseudomonas aerogenosa using Kirby-Bauer  disc diffusion  and serial dilution method The antibacterial effects of  aquous and  methanolic plants extract  of  Azadirachta indica leaves extracts, were analysed  and there was no zone of inhibition was found against MRSA at all dilution. zone of inhibition against Escherichia coli , at pure concentration    was 28mm. zone of inhibition against pseudomonas aerogenosa at pure concentration was 16mm. zone of inhibition against Klebsiella pneumonaie at pure concentration was 13mm.Similarly we determined the antibacterial effects of  aquous and  methanolic plants extract  of  Methi (Trigonella foenum-graecum)  was analysed and  measured highest zone of inhibition at pure concentration  against pseudomonas aerogenosa of 14mm and zone of inhibition of 12mm against E.coli was measured, zone of inhibition of 6mm  at pure concentration  was measured against MRSA and no zone of inhibition was measured  against  klebsiella pneumonaie at all concentration . These plant extracts which proved to be potentially effective can be used as natural alternative preventives to control infection.

Keywords

Azadirachta indica, Trigonella foenum-graecum, Antibacterial