In this review, the several sets have described important influences in Suzuki–Miyaura (SM) coupling process in carbon-based production Suzuki cross coupling reaction remains one of the greatest well-known process in the field of chemistry. It remains actual active process for manufacture C-C links. In this review, we have concentrated on the application of cross-coupling reactions like Suzuki in the whole production of certain natural-products of latest years. It takes been far used in the manufacturing of several C particles including the greatest compound ones. Fundamentally compound alkaloids, terpenoids, steroids, polyketide natural products, iso-lated from a diversity of aquatic as well as native bases, remain to give an appreciated source of worthwhile goals for the man-made chemist to challenge. The current review article highlighting on C-C link development like cross coupling reaction, mechanism as well as use in a natural-product production.