The infection which are transfer through blood is called transfusion transmissible infections. It is a type of communicable infection. Communicable infection are those infections which are transfer from one individual to another through direct contact, air sole, sexual contact, or through blood infections. The most prominent among these infections are Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus, Syphilis and Malaria. The study was conducted on Volunteer blood donors in District Peshawar Khyber Pakhtunkhwa Pakistan. It is Retrospective study. The blood of 6378 donors was screened in this study. The Positive rate was 2.15%. The prevalence rate of Hepatitis B Virus infection was 1.3%, Hepatitis C Virus infection was 0.7%, Human Immunodeficiency Virus infection was 0.1%. The prevalence rate of Treponema Pallidum infection is 0.03% and Plasmodium Malaria is 0.0%. Strict selection criteria for blood donors are required during blood donation. Use of standard methods needs for screening of blood donors for Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus, Syphilis and malaria. Blood donors history is necessary. All Standard Operation Procedure during Examination of blood should be followed which is the basic step to prevent these infections.

Keywords: Screening, Regional Blood Centre, Khyber Pakhtunkhwa, Peshawar, Pakistan