Background: In the presence of different drugs for treatment many people still experience different diseases. The available drugs have many side effects, which required a search for new drugs from several sources in which medicinal plants are the major one this study evaluated the analgesic and anti- inflammatory activity of the solvent fractions of Chenopodium ficifolium in rodent models of pain and inflammation.                                                                 Methods: Successive maceration method were used for extractions using solvents; chloroform, n-hexane, ethyl acetate and water. Albino mice, acetic acid induced writhing and carrageenan induced paw edema were used to assess the analgesic and anti-inflammatory activity. The test groups received different doses (100 mg/kg, and 200 mg/kg) of the four fractions (chloroform, n-hexane, ethyl acetate and aqueous).                                                                 Results: In all models, the n- hexane fraction had protections to reduce paw edema only at a dose of 200 mg/kg. However, the ethyl acetate fraction shown significant analgesic activities with a comparable result to the standards. Conclusion: The C.ficifolium having the resistance against inflammation and analgesia by different agent.  It is farther suggested to evaluate the anti-spasmodic and anti-pyretic activities.

Keywords: inflammation, analgesia, C.ficifolium