Background: Dengue fever, spread by the Aedes aegypti mosquito, is an arboviral infectious disease endemic to arid and semiarid regions of the globe. Several body organs, i.e. heart, kidney, liver, pancreas, eyes, and central nervous system, are affected by dengue fever in various ways. Aim/Objective: The current study is aimed to assess reproductive dysfunction in dengue patients. Methodology: Blood samples of 40 male patients with DF (dengue fever) and SDF (Severe dengue fever) and 30 healthy males of the same age group as the controls were collected. Blood was drawn and processed so that the serum could be separated to assess the levels of the reproductive hormones. The hormonal analysis was done through ELISA, and obtained data were analyzed statistically using One-Way ANOVA through IBM-SPSS software. Results: Results showed that FSH level increased significantly (P=0.039) in dengue patients' groups compared to controls. Similarly, the level of the LH prominently (P≤0.001) elevated in the patients' groups compared to controls. However, there was a significant (P≤0.001) decrease in serum testosterone levels (hypogonadism) in dengue patients' groups compared to controls. Conclusion: It was concluded, from the above results, that the infected patients have a disruption in reproductive hormone production which can lead to hypogonadism, ultimately.

Index Terms- FSH; LH; Hypogonadism; dengue fever