The inevitable significance of medicinal plants has been accepted worldwide for curing and treatment purposes. Likewise, Opuntia monocantha (OM) was implicated traditionally for numerous pathologies due to diversified pharmacological activities. The current study was focused on elucidating the hepato-protective and anti-inflammatory potential of OM in MnCl₂ induced hepatotoxicity and liver inflammation. The MnCl₂ was administered at a dose of 6.0 mg/kg for 30 days (p.o) to induce hepatotoxicity and liver inflammation. An in vivo model was employed for investigating hepato-protective effect of orally given ethanolic extract of OM. Outcomes revealed that administration of ethanolic extract of OM at different doses (250, 500, and 750 mg/kg) remarkably reduced oxidative stress and hepatic inflammation. Moreover, histopathological observations were compared with diseased rats which supported protective effect of plant extract. Therefore, protective effect of ethanolic extract of OM was exhibited in wrister rats by attenuating liver inflammation an oxidative stress.

Keywords: Inflammation, Celecoxib, oxidative stress, Opuntia monocantha, MnCl₂