Introduction: Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo that presents in an ENT clinic. Various repositioning maneuvers and treatment therapies exist for its management.

Objective: To compare the efficacy of Semont's maneuver and beta histidine (vasodilator) in the management of benign paroxysmal positional vertigo.

Methods and Materials:

Setting: ENT Department of Hayatabad Medical Complex Peshawar.

Study Design: Randomized Clinical Trial

Duration of study: From February 26, 2019, to August 26, 2019.

Sample Size: The total sample size will be 104 (52 in each group), keeping the efficacy of Semont's Maneuver 88% and the efficacy of Beta Histidine 57% using the level of significance 1%, power of test 90% according to the WHO formula for sample size.

Sampling technique: Non-probability consecutive sampling

Results: Group A (Semont's maneuver) was effective in 90% of patients and was not effective in 10% of patients. Whereas Group B (beta histidine vasodilator) was effective in 62% of patients and was not effective in 38% of patients.

Conclusion: Our study concludes that Semont's maneuver is more effective than beta histidine (vasodilator) in the management of benign paroxysmal positional vertigo.