Background: Knee osteoarthritis is a progressive degenerative joint disease characterized with severe pain, stiffness, functional disability and various degree of inflammation. 

Objective: To evaluate the comparative effects of muscle energy and mobilization with movement techniques for knee pain, Range of motion and functional disability in patients with knee Osteoarthritis.

Methodology: A randomized clinical trial was conducted at Physiotherapy Department of Bakhtawar Amin College of Rehabilitation Sciences, Multan. Patients of age 40-60 years with active pain for more than 3 months diagnosed with Grade I, II and III of knee osteoarthritis by orthopedic surgeon according to Kellgren and Lawrence Scale and on basis of radiograph were included. Patients with knee osteoarthritis of grade IV, history of fracture dislocation or radiating pain were excluded. Sixty-eight (68) patients were equally divided in two groups Mulligan group and METs group. Pain intensity was measured with NPRS, functional disability was measured with WOMAC score, and knee flexion and extension were measured with universal goniometer. Patients were treated 3 times a week and for total 04 weeks. Data were collected at base line, middle of treatment and after treatment. 4 Patients from METs group and 6 from Mulligan group discontinued the treatment plan without giving any reason. The data of 28^th patients of Mulligan’s group and 30^th of MET’s were analyzed through SPSS version 24.

Results: The data were normally distributed at baseline in both groups.  Two groups Mulligan and METs were compared at base line, after 2^nd week and 4^th week. Pain intensity was 0.19 (p<0.01), WOMAC score was 0.007(p<0.01) Knee flexion was 0.110(P<0.995) and Knee extension deficit score was 0.087 (P<0.998). Coefficient alpha for with in group subject effect for pain, functional disability and knee flexion and extension deficit is (P≤0.05).

Conclusion: Both techniques post isometric relaxation technique of METs and mobilization with movement technique of Mulligans significantly reduced pain, functional disability and symptoms severity and are equally effective in patients with knee osteoarthritis.

Key words: Knee Osteoarthritis, Post Isometric Relaxation, Mobilization with Movement, Muscle Energy Technique,