Present study was undertaken to evaluate the biochemical composition including CBC and phenotypic traits obtained from cross breeding of Desi and Fayoumi chickens. Samples were collected from local peoples and hatcheries of district Kashmore and transported to intensive care management system at animal house department of zoology Shah Abdul Latif University Khairpur, mirs. Both chickens’ populations were reared and F1 generation chickens were obtained by recommended cross formula. The phenotypic traits like comb lengths and beak sizes were noted high in such sequences as Desi>Desi F1>Fayoumi F1>Fayoumi chickens in different stages of growth. Mortality rates were observed high in Fayoumi breed as compared to Desi breed during both sessions, while in winter Fayoumi death rates were in highest in winter due to pulmonary infections. Health protocols like vaccination and immune boosters were introduced to flocks under guidance’s of local veterinary officials. Feeding and rearing procedures were followed by NRC and ISA recommended guidelines.

Key Words: Chickens, Phenotype, Genetic traits, Cross breeding