In this study, we studied the effectiveness of the new domestic blood substitute containing amino acids and the natural energy metabolite of the Krebs cycle in experimental protein starvation. The aim of the study was to assess the degree of influence of a new domestic amino acid preparation on metabolic homeostasis during protein starvation. Materials and methods. The experiments were performed on 30 male rabbits weighing 2.2-0.2 kg on a model of protein starvation. In dynamics were investigated: the state of the general antioxidant status, indicators of the blood coagulation system, hematological, biochemical parameters of blood and renal function. For comparison, the drug "Infezol-40" was used. Results. A study of a new domestic blood substitute containing amino acids in comparison with the Infezol 40 preparation confirmed the higher efficiency of the new domestic blood substitute in restoring the antioxidant status parameters, hemostasis parameters, blood biochemical parameters and kidney function.

Key words: amino acids, homeostasis, antioxidant status, hemostasis, biochemical analysis, kidney function.