The present study was aimed to investigate  the curative effects of Ziziphus oxyphylla   (Z.O)  leaves aqueous  extract on bioaccumulation of heavy metals along with blood and biochemical variables in Puntius ticto . The heavey metals such as Zn, Ni,  Cd and Cr were analysed in muscle, liver, gills, skin and intestine  while, complete hematology , lipid profile and some liver and kidney  related biochemical parametes were analyzed.  The fish were first exposed to CaCl₂ and  then treted with extract of (Z.O)  alone and along with ascorbic acid.  The results showed that all the tissues accumulate the substitutional amount of heavy metals.  The accumulation of Zn was highest and Ni come second followed by Cr and in the last and least was Cd respectively i.e. Zn>Ni> Cd>Cr. This accumulation was differential in each organ studied such as in the skin the accumulation was highest while in intestine it was high and followed by gills then muscles tissues. However, the accumulation was least in the liver tissues.  Analysis of blood and serum indices revealed that extract alone (group 2) has no effect while the co administration of extract and ascorbic acid (group 3) significantly ameliorates the altered hematological and biochemical parameters toward normal levels when compared to normal control fish (group 1).

Key words: Puntius tict, Bioaccumulation, Heavy metals, Skin, Gills and Muscles