In the current study, we have evaluated the therapeutic efficacy of two Nanoparticles i.e. copper sulphate (CuSO₄) and silver Nitrate (AgNO₃) isolated from Skimmia lareoula against Alloxan induced hyperglycemia and oxidative stress mediated neuroinflammation and memory dysfunction in male adult albino mice brains. The results indicate that both nanoparticles significantly reduced Alloxan-induced hyperglycemia oxidative stress, neuroinflammation neurodegeneration accompanied by the improvement in memory and behavior via TLR-4 /COX2 / IL-1β signaling pathway. Copper sulphate show more significant result comparative to silver nitrate. In summary, these results indicate that these two nanoparticles are natural, potent, safe and easily available therapeutic agents and acts as a drug candidate to treat diabetes mediated AD pathology in adult mice.

Index Terms- Copper sulphate, hyperglycemia oxidative stress, silver nitrate, Skimmia lareoula and signaling pathway.