Background: Osteoporosis is the most common bone pathology in the world. It has a multifactorial pathophysiology which is only partially understood. Recently there has been some interest in the role of HSPs in the pathophysiology of osteoporosis but the available data are limited.

Objectives: Aim of this study is to correlate relationship between heat shock proteins (HSPs) and osteoporosis by comparing serum levels of HSP-27, 70 and 90 in osteoporotic patients with controls (healthy individuals).

Methodology: A cross sectional comparative study was thus designed. Fifty (50) self-reported healthy age matched controls were recruited from local population. Fifty (50) patients were diagnosed according to the protocol of The International Society for Clinical Densitometry. Premenopausal women presenting with fragility fractures and BMD Z-score less than or equal to –2 were diagnosed as osteoporosis patients. Five ml of blood was taken and serum was separated for biochemical analysis of HSP-27, HSP-90, HSP-70 using human ELISA kits (Bio-Vendor). Statistical analysis was performed by SPSS statistics 17.0.

Results: Mean values of HSP-27, HSP-70 and HSP-90 were raised in osteoporotic females in comparison with controls at p=0.001, p=0.04 and p=0.02 respectively.