An accurate, precise, and highly selective spectrophotometric method was determined the estimation of mirabegron for quality control tests in pharmaceutical dosage forms. The method involves the measurement of absorbance at a wavelength of 251 nm. Validation was performed according to ICH guidelines. Beers law obeyed in the concentration range of 2-14 µg/mL, were found to be linear. It showed good reproducibility and recovery with a relative standard deviation of less than 2 %. The limit of detection and quantification was found to be 0.15 and 0.48 µg/mL. Thus, the proposed method was found to be specific in the presence of other excipients, precise and accurate quality control tools for routine analysis of mirabegron in pharmaceutical dosage form.

Keywords: Mirabegron, Spectrophotometry, Quality control, ICH, Validation, Beers law