Drugs regularly used for the management of the retroviral infection mostly exist as conventional dosage forms. The main short coming of these dosage forms are non specific or non targeting delivery of the drug in the site of action. Drug delivery systems by means of colloidal particulate carriers such as liposomes, niosomes have distinct advantages over conventional dosage forms because the particles can act as drug containing reservoirs, and modification of the particle composition or surface can adjust the drug release rate and/or the affinity for the target site.

Aim & Objective: The aim of the present study was to formulate zidovudine proniosomes as stable precurs or for the oral drug delivery system. To get the preferred characteristics of a proniosome formulation of hydrophilic drug zidovudine in the presence of cholesterol, it is important to select theproper surfactant. Another objective of this study is to compare the effect.

Methodology: Screening of drugs, Evaluate organoleptic property, particle size, solubility and partition co-efficient of selected drug. Drug excipients compatibility studies to confirm absence of any interaction between drug and excipients. Determination of zidovudine amount to be used in a proniosome formulation. Preparation of calibration curve of drug. Formulation development of proniosome formulation Physico chemical characterization of prepared proniosome formulations and selection of best formulation in each category based on the evaluation. Invitro drug release study of pronoisome formulations. Stability study of best proniosome formulation. 

Results & Discussion: In the present study a challenge was taken to encapsulate hydrophililic anti retroviral drug  zidovudine  in malto dextrin based novel proniosome formulations.

Conclusion: Presently proniosomes have been studied by investigators as a preference of oral drug delivery system for antiretroviral drugs to provide a better oral bioavailability considering, targeted delivery, minimize the adverse effects, prolonged release of the niosome encapsulated medicaments through biological membrane and the stability of them. On conclusion, the zidovudine novel proniosome drug delivery system represent a significant improvement in all evaluation parameters. To summarize the above mentioned outcomes, water soluble drug zidovudine was fruitfully incorporated into proniosomes.

Key Words: Zidovudine, Proniosomes, Oral, Drug Delivery.