Background: Diabetes mellitus is one of the leading diseases that are engulfing the world fast. According to an estimate, 347million peoples are suffering from diabetes mellitus (DM) in Pakistan. Diabetes mallitus leads to hypomagnesemia while alcohol misuse in diabetes mallitus further worsen the condition. Magnesium critically stabilizes different enzymatic reactions, including many
АTP generating reactions.

Aims and objectives: The aim and objective of this study was to evaluate the relationship between serum magnesium level and diabetes mellitus in association with alcoholism.

Methodology: The present study was conducted at the Department of Biochemistry in collaboration with the Department of OPD and the Department of Causality (COD). It was a cross-sectional and comparative type of study. One hundred and ten (110) participants were included to participate in this study. Seventy (70) were in the control group and 40 were in the test group. The study was conducted according to a specific inclusion and exclusion criteria. Roche C311 auto analyzer was utilized to analyze the serum magnesium level.

Results: The results obtained were incorporated in a specific designed Performa. The data was analyzed by SPSS version 23. It was concluded that in patients suffering from diabetes mellitus and are consuming alcohol have more chances of developing Hypomagnesaemia than those diabetic patients do not use alcohol (P value 0.000). The study found that frequency of drinking is also closely associated with development of Hypomagnesaemia (P value 0.002). Recommendation was sent to LUHMS.

Conclusion: It was concluded that that there is a direct association between diabetes mellitus and low serum magnesium level and this association become far greater in patients who are regular user of alcohol.

Keywords: Diabetes Mellitus, Hypomagnesaemia and Alcohol