Background: Various drug classes are available for the management of dyslipidemia but due to their toxicities the focus has been shifted to experiment herbal adjuvants to treat the condition. In this regard the current study evaluated and compared the alterations in lipid-profiles of fat-induced dyslipidemic rats when treated with chia seeds and rosuvastatin.

Methodology: It was a preclinical experimental study, conducted at Baqai medical University Karachi. Male Wistar albino rats of 9 weeks age, 200-250g weight were divided into 5 groups such as 6 rats per group. Coconut oil and Banaspati ghee were administered to induce dyslipidemia in animal groups (2, 3, 4, and 5) at the dose of 10ml/kg for 28 days and weight of animal was measured before and after the protocol. After the 28^th day, intervention as per grouping of the animals was started for next 28 days, chia seed powder and rosuvastatin suspended in distilled water was administered via 20g feeding needle directly into the stomach of animals. After 8 weeks the animals were sacrificed under euthanasia (100mg/kg pentobarbital) and blood was withdrawn via cardiac puncture for evaluation of lipid profile of all animals.

Results: The paired analysis for weight displayed a significant (p=<0.005) increase in weight of animals after administration of high fat diet. Conversely, a significant decrease in weight was observed after administration of chia seeds powder and rosuvastatin in group 2, 3, 4, and 5. Further to this lipid profile of animals highlighted a significant (p=<0.05) increase in total cholesterol triglyceride and LDL level after induction of dyslipidemia however, HDL, Urea and Creatinine level remained non-significant. The anova highlighted that chia seed powder at 50mg and 100 mg dose reduced total cholesterol, triglyceride and LDL level equivalent to rosuvastatin (group 5) and did not alter the HDL, Urea and Creatinine.

Conclusion: Chia seeds at both the doses i.e. 50mg and 100mg decreased weight of animals and modulated hematological parameters equivalent to rosuvastatin.

Key Words: Chia seeds, rosuvastatin, dyslipidemia, Animal