Samanea saman species are endemic to the Indian subcontinent. It is a large tree as high as sixty meters tall. It has a wide variety of medicinal properties especially in the treatment of gastrointestinal disorders, liver disorders, and respiratory tract problems. The present research work was aimed to carry out the green synthesis of silver nano particle of Samanea saman leaf extract and to investigate the antitubercular perspectives. The extraction was carried out by using eco-friendly solvent such as water. It was further characterized by UV and IR spectroscopic studies.  The antitubercular activity was screened by using Alamar blue assay method and the opportunistic pathogens were screened by Disc diffusion method. The UV absorption data analysis reveals the Surface Plasmon Resonance around 430nm. The antitubercular activity by Alamar blue assay results explored that the silver nano particle synthesized by using leaf extract of Samanea saman exhibit minimum inhibitory concentration of 1.6 µg/ml. The Silver nano particle of the extract has also shown activity against opportunistic pathogens which are associated with tuberculosis.

Key words:Green synthesis; Silver nano particle; Samanea saman; Alamar blue assay