Fibromyalgia is a chronic, extensive musculoskeletal pain and associated fatigue, sleep disturbance, and other cognitive and physical symptoms. Studies have indicated that different cytokines and chemokine’s play an important role in inducing symptoms like pain, fatigue, fibromyalgia, etc. The primary objective of the current study was to stipulate the role of up regulated cytokines in the development of fibromyalgia. A total of 300 participants were recruited in this study divided into 150 healthy control and 150 diseased groups. After getting an informed consent, 5ml of blood was drawn into specialized vials for the analysis of various markers. For the quantification of different cytokines, the enzyme linked immunosorbent assay was used. Levels of lipid peroxidation products such as MDA, IsoP, 8-OHdG, 4-HNE followed by the cytokines remained significantly higher among the patients when compared to healthy individuals. Levels of IL-1, 2, 4, 6, 8, 13 and 17 remained significantly higher among the group of Fibromyalgia patients Findings of the study stipulate the role of elevated levels of cytokines and other stress markers in the development and progression of the disease condition among the subject group. It states how elevated levels of interleukins can significantly increase the chances of developing FM conditions among patients. Therefore, the interleukins may serve as potential predictors to down regulate the progression of fibromyalgia.

Keywords: Fibromyalgia, Cytokines, MDA, IsoP, 8-OHdG, 4-HNE