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Complications related to type 2 diabetes (T2DM) and treatments in a population of NADOR in the NORTH of MOROCCO

. Ikram kenfaoui1, Hamada Imtara2, Hamza El Azhari3, Imane Boussenna4, Brahim Outemsaa1, Asmaa oubihi1 , Abderrahim Benzakour1, Mohammed Ouhssine1


Abstract

Introduction: Type 2 diabetes is prone to numerous complications that arise from complex mechanisms involving hyperglycemia, insulin resistance, low-grade inflammation and accelerated atherogenesis. Cardiocerebrovascular complications affect the prognosis of diabetes. Objective: The present study is to investigate T2DM-related complications and treatments in a population of NADOR in the NORTH of MOROCCO. Material and methods: This study was conducted in a private laboratory of medical analysis in the city of NADOR over a period of one year from 01 / 10 / 2018 to 01 / 10 / 2019. This epidemiological study was carried out on 830 male and female subjects aged 18 years and over who reside in the city of Nador. The collected data were entered in Excel, after filtration and coding we transmitted them on a statistical exploitation support SPSS (Statistical Package for Social Sciences) version 23.0. Quantitative variables were expressed as means ± standard deviation, and qualitative variables as frequencies and percentages. The hypothesis tests applied to compare the means and proportions are respectively T Student and the Chi-2 test of independence. Fasting blood glucose was determined by an automated biochemistry machine after 5 min of decantation and 10 min of centrifugation. HbA1c was determined on whole blood by an HPLC (High Performance Liquid Chromatography) machine. Results: Our population had a mean fasting blood glucose level of 2.32±0.78 g /l, glycated hemoglobin above 9% was the majority in our population (47.70%) followed by the range between [7-8%] and then [8-9%] and then below 7%. complications, we find that renal failure is the most common complication of T2DM in our population with a rate of 18.19% followed by 17.23% of patients with hypertension, and 14.83% had dyslipidemia, all our patients had complications related to T2DM. In our population 93.5% used Oral Antidiabetics (OADs) divided into 65.8% of the population treated with Sulfonamides versus 27.7% uses Biguanides, thus OAD treatment was the most used therapy in our study population. The combination of ADO and insulin therapy had a rate of 3.37% versus 2.3% of insulin therapy (1.3% definitive insulin therapy and 1% transient). Conclusion: The results show the important role of self-monitoring of blood glucose and HbA1c in achieving glycemic control in diabetics treated with oral antidiabetic drugs, and the need to develop a strategy to improve the quality of management of type 2 diabetes.

Key words: diabetes, type 2 diabetes, management, glycemic control, self-monitoring of blood glucose, glycemic control, ADO, HTA, Nador.

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