Background:

Diabetes mellitus is a common metabolic disorder, represented by hyperglycemia and chronic hyperglycemia is associated with long-term complications. There is much evidence that oxidative stress is involved in the origination of several diabetic complications. Oxidative stress occurs when the production of oxidant exceeds the rate of oxidant scavenging. Thus the all individual antioxidant markers may deliver more appropriate information compared to that obtained by the measurement of total antioxidant capacity.

Aims and Objectives: The aim of this study evaluates the status of oxidative stress in type 2 diabetic patients and non-diabetic healthy individuals and the correlation between the antioxidant level and hyperglycemia.

Material and Methods: A total 140 individual were chosen, 70 patients with Type-2DM from the last 1-2 years and 70 normal healthy individuals as a control group of both sexes. All subjects were undergo to the following investigated parameters; BSL (F, PP), Vitamin C, Vitamin E, Catalase, MDA, SOD, Glutathione peroxidase, and Glutathione reductase enzymes.

Results: The mean values of BSL (F, PP) and HbA1c were significantly increased (P<0.001) in patients as compared to control. Whereas the mean value of Vitamin C, E, Catalase, SOD, Glutathione peroxidase, and Glutathione reductase enzymes was significantly decreased in Type-2 diabetic patients as compared to control. The value of malondialdehyde (MDA) was significantly increased in diabetic patients as compared to control.

Conclusion:  The antioxidant and oxidative stress markers can be used for follow-up in patients suffering from diabetes mellitus type 2 and predict other complications.

Keywords: Diabetes Mellitus, Antioxidants, oxidative stress, Free Radicals