This study examines the efficiency of public universities in south-western Nigeria in comparison with the other universities employing the Data Envelopment Analysis (DEA) technique. Although the focus is South-Western Nigeria, the study examined 121 universities spread among four categories of owners (40 Federal, 30 States, 29 privates and 23 faithbased). Data for the study were based on the year 2017 and were sourced from the Nigerian University System Statistical Digest and The State of Nigeria Universities both of the National Universities Commission. Results reveal that on the average, universities in the South-West are not technically efficient. However, the most efficient Nigeria public SouthWest universities are found to be Federal universities. The plausible outcome of this research is that federal universities are the efficient ones. Federal universities from the North Central zone of the country were also found to be better than those from the South-West. None of the state universities which are usually plagued with perennial financial crisis is efficient. The study calls for mechanisms to re-strategize and to get these public universities to be more financially buoyant and strong in order to deliver on their various missions and mandate. 
 
Kewords: Efficiency, South-West, Education, Data Envelopment Analysis