In an attempt to find out the phytochemical screening for four medicinal plants like Andrographis paniculate, Centella asiatica, Psidium guajava, and Solanum trilobatum were studied. Five different solvents viz. petroleum ether, benzene, chloroform, and ethanol were used to obtain extracts from producing plant leaves. The extracts were subjected to qualitative phytochemical screening using standard procedure. The ethanolic plant extract was found to be more phytochemical than the other extract. The ethanolic extracts have been tested individually and in combination for their antimicrobial activity against Streptococcus pneumoniae (mm) and Klebsiella pneumoniae (mm) Strains. Results showed that the combination of plant extracts have higher antimicrobial activity than the individual plant extract. The four-plant extract ratio (1:1:1:1) of Andrographis paniculate: Centella asiatica: Psidium guajava: Solanum trilobatum was found to exhibit comparable activity (28 mm and 26 mm) than that of Amoxicillin (27 mm and 25 mm) and other combination (Two-plant and three-plant extracts) and individual plant extracts against Streptococcus pneumoniae and Klebsiella pneumoniae.  Regarding the three-plant extract moderate antimicrobial activity against Streptococcus pneumoniae and Klebsiella pneumoniae were noticed.

Key words: Anti-pneumonia activity, phytochemical, synergistic activity, Andrographis paniculate: Centella asiatica:Psidium guajava: Solanum trilobatum