Current work was carried out on dissolution apparatus (USP) that helps drug release of Vitamin cholecalciferol (D3) in dissolution process followed by dissolution monograph, that helps for the quantification of drug available in biological fluid at gastrointestinal tract and significant factors involved in change of pH of medium and agitation of dissolution media. The experiment results exhibited better drug release for Cholecalciferol Tablets (D3) drug in 0.1 N HCL and acidic buffer than pH 6.8 buffer with different agitation speeds.

Keywords: Vitamin cholecalciferol, buffers, Dissolution apparatus and Tablets