Alzheimers Disease ( AD), a widespread type of dementia, has a major effect on millions of people worldwide. Interestingly, with recent developments in nanotechnology such as the Nanodrug delivery method, which merits high specificity for brain endothelial cells, early detection of AD is probable. Due to its special radical scavenging feature, Cerium Oxide nanoparticles (CNP) were selected as a drug carrier in the present analysis, and CNP was synthesised by the Green synthesis process. The green synthesis of ceirum oxide nanoparticles prepared was subjected to neuroprotective in vitro and in vivo assessment. The findings show that CNPs Green synthesis is a promising and powerful formulation for AD. The CNP and anti-aantioxidant activity and  free radical scavenging behaviour of the green synthesis of cerium oxide nanoparticles can be due to synergistic activity that enhances ADs neuroprotective and cognitive enhancement activity.

Keywords:

Cerium oxide nanoparticles (CNP), Reactive oxygen species ( ROS), Synergism, Alzheimers Disease (AD).