Herein, the authors have presented a facile synthetic route of mesoporous nanoparticles (MSNs), and their structural characterization with their use to be an efficient drug delivery channel for diclofenac sodium. X-ray diffraction measurements (XRD), and Fourier transform infrared spectroscopy were used to track the alteration of the parent nanoparticles. By varying the quantity of co-solvent introduced to the sol-gel solution, the MSNs formed had the varied particle morphological characteristics of the microporosity has aided in the management of particle shape and structure. MSNs having an average diameter of 200 nm and dual pore channel sections featuring pore sizes of 1.3–2.6 and 4 nm were investigated as drug carriers. The impact of multimodal pore systems on the precise discharge of the experimental pharmaceutical diclofenac sodium was studied. The diclofenac-loaded MS nanoparticles were then studied for their drug release ability, which was altered owing to morphological variations. MSNs proved a dispersion of their drug release behavior showing a continual supply of the drug in vitro. The results showed that the diclofenac sodium release pattern proves discrete zones, which may be attributable to the corresponding porosity channel zones contained on the nanoparticles. The multifunctional pore channel networks handled the changes in drug concentration during the extended release through MSNs. The mesopore design and customizable surface of mesoporous silica nanoparticles enable the inclusion of a variety of therapeutic compounds and regulated distribution to specific areas.

Index Terms- Mesoporous nanoparticles, Diclofenac, SEM, XRD, Drug delivery